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Accidental ingestion of oxycodone and acetaminophen tablets, Primarily by children, may lead to respiratory despair and Demise as a consequence of an overdose of oxycodone and acetaminophen tablets.

Opioids are sought by drug abusers and those with habit Diseases and so are topic to criminal diversion. Contemplate these threats when prescribing or dispensing oxycodone and acetaminophen tablets. Approaches to reduce these hazards include prescribing the drug inside the smallest acceptable amount and advising the affected person on the proper disposal of unused drug [see Safety measures; Data FOR Individuals/CAREGIVERS].

Take into consideration prescribing naloxone, depending on the client's chance components for overdose, such as concomitant usage of other CNS depressants, a heritage of opioid use condition, or prior opioid overdose. The presence of possibility aspects for overdose mustn't prevent the proper administration of pain in almost any offered affected person. Also contemplate prescribing naloxone In the event the affected individual has household users (including little ones) or other shut contacts at risk for accidental ingestion or overdose.

This isn't a whole listing of doable Uncomfortable side effects. When you discover other outcomes not mentioned over, Make contact with your medical doctor or pharmacist.

Teach people and caregivers on how to recognize respiratory melancholy and emphasize the necessity of calling 911 or finding crisis health care aid instantly while in the event of the known or suspected overdose [see WARNINGS; Lifetime-Threatening Respiratory Despair].

Check patients carefully for respiratory depression, Specifically throughout the to start with 24 to seventy two several hours of initiating therapy and adhering to dosage increases with oxycodone and acetaminophen tablets and alter the dosage accordingly [see WARNINGS].

Bodily dependence is often a physiological condition in which the human body adapts into the drug following a period of standard exposure, causing withdrawal signs right after abrupt discontinuation or a major dosage reduction of a drug. Withdrawal also might be precipitated throughout here the administration of prescription drugs with opioid antagonist exercise (e.

Prolonged-term reports to evaluate the carcinogenic opportunity of The mix of oxycodone and acetaminophen haven't been conducted.

Clarify to people and caregivers that naloxone's results are short term, and they should get in touch with 911 or get emergency healthcare assist without delay in all conditions of known or suspected opioid overdose, although naloxone is administered [see OVERDOSAGE].

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Anaphylaxis: Anaphylaxis has become documented with components contained in oxycodone and acetaminophen tablets.

Inquire your health practitioner or pharmacist if you need to have naloxone available to treat opioid overdose. Train Your loved ones or domestic users in regards to the indications of an opioid overdose and how to handle it.

Oxycodone is excreted in breast milk in reduced concentrations, and there are actually unusual reviews of somnolence and lethargy in toddlers of nursing mothers taking an oxycodone/acetaminophen product or service. Acetaminophen is also excreted in breast milk in very low concentrations.

Examine the availability of naloxone for the emergency cure of opioid overdose Using the affected person and caregiver and assess the potential need for usage of naloxone, the two when initiating and renewing therapy with oxycodone and acetaminophen tablets. Inform individuals and caregivers about the different ways to get naloxone as permitted by particular person condition naloxone dispensing and prescribing prerequisites or guidelines (e.